Details

Autor(en) / Beteiligte

• Yang, Zichen
• Yao, Tianyu
• Zheng, Xiaoyan
• Hui, Junfeng
• Fan, Daidi

Titel

Eu3+/Tb3+-doped whitlockite nanocrystals: Controllable synthesis, cell imaging, and the degradation process in the bone reconstruction

Ist Teil von

• Nano research, 2022-02, Vol.15 (2), p.1303-1309

Ort / Verlag

Beijing: Tsinghua University Press

Erscheinungsjahr

2022

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Whitlockite (WH, Ca 18 Mg 2 (HPO 4 ) 2 (PO 4 ) 12 ) is an important inorganic phase in human bones and has positive significance for participating in the bone reconstruction process. In this paper, we report different doping strategies to prepare WH and WH-Ln (Eu/Tb) nanocrystals, and have successfully synthesized WH-Ln (Eu/Tb) nanoparticles (NPs) with bright red or green fluorescence based on ions exchange doping by two-step hydrothermal reaction. WH-5%Ln (Eu/Tb) NPs with the best fluorescence properties were successfully applied to live cell imaging, and WH-5%Eu NPs were implanted into the bone defect site in rabbit femoral condyles to visually observe its degradation process. The related results would help us understand WH nanocrystals and further expand their potential applications in tissue engineering and related fields.