Details

Autor(en) / Beteiligte

• Yi, Xiao
• Chen, Yirui
• Huang, An
• Song, Dingguo
• He, Jiaying
• Ling, Fei
• Zhong, Weihui

Titel

Design of chiral ferrocenylphosphine-spiro phosphonamidite ligands for ruthenium-catalyzed highly enantioselective coupling of 1,2-diols with amines

Ist Teil von

• Organic Chemistry Frontiers, 2021-12, Vol.8 (24), p.6830-6836

Ort / Verlag

London: Royal Society of Chemistry

Erscheinungsjahr

2021

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A series of chiral ferrocene-backbone phosphines-spiro phosphonamidite ligands was developed for ruthenium-catalyzed enantioselective access to a broad range of β-amino alcohols from 1,2-diols and amines via the borrowing-hydrogen prciniple. Up to >99% ee with a broad substrate scope was attained. Late-stage functionalization of drugs and natural products were realized by means of this route. Data from density-functional-theory studies were in good agreement with experimental results.