Details

Autor(en) / Beteiligte

• Sugi, Tomiyuki
• Mita, Mitsuo
• Yasu, Takeo
• Ohara, Shin
• Uchida, Tomoyuki
• Inoue, Morihiro
• Hagihara, Masao

Titel

Simple desensitization protocol for multiple myeloma patients with lenalidomide‐induced skin rash: Case series

Ist Teil von

• Journal of clinical pharmacy and therapeutics, 2021-12, Vol.46 (6), p.1792-1795

Ort / Verlag

England: Hindawi Limited

Erscheinungsjahr

2021

Quelle

MEDLINE

Beschreibungen/Notizen

• What is known and objective Skin rash is one of the typical side effects of lenalidomide (LEN) treatment. Desensitization therapies have been reported to be effective in patients with severe skin rash caused by LEN. However, they have proved impractical due to the complexity of the protocols. Case summaries We present 5 patients who developed severe LEN‐induced skin rash. The five patients received our simple, slow desensitization protocol, and all were re‐administered LEN with no adverse reaction. What is new and Conclusion Our simpler and slow desensitization protocol, which desensitizes the patients without reducing the effect of LEN, includes drug holidays, similar to the usual LEN dosing schedule, and moreover is recommended as a treatment option especially for elderly patients with no housemate to help with medical management. We have changed the desensitization protocol for lenalidomide reported previously to a simple one, which can be easily performed on elderly MM patients. Using the protocol, this desensitization therapy was successful in all patients with severe skin rash caused by lenalidomide.