Details

Autor(en) / Beteiligte

• Sarmini, Muhammad Talal
• Asfari, Mohammad Maysara
• Al-Khadra, Yasser
• Dasarathy, Srinivasan
• McCullough, Arthur

Titel

Assessing the Risk of Osteoporosis in Patients with Inflammatory Bowel Disease: 657

Ist Teil von

• The American journal of gastroenterology, 2018-10, Vol.113 (Supplement), p.S374-S374

Ort / Verlag

New York: Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins

Erscheinungsjahr

2018

Beschreibungen/Notizen

• Introduction: It is well known that patients with inflammatory bowel disease (IBD) are at higher risk to develop osteoporosis. IBD can affect bone mineralization in multiple pathways including malabsorption, recurrent steroids use and increased inflammatory response. However, IBD patients have many potential confounders that also cause osteoporosis independent from IBD. Therefore we conducted this study to establish if IBD is an independent risk factor for the development of osteoporosis. Methods: Using data from the National Inpatient Sample (NIS) database between 2002 and 2014, we identified patients who were diagnosed with IBD and were compared to patients without IBD. We performed multivariate logistic regression analysis for the association between IBD and osteoporosis. Results: The total population was comprised of 101,020,258 patients, of which 704868 (0.69%) were diagnosed with IBD. IBD patients were older (50 vs 48) with more females (58.4% vs 57.3%) and more African American patients (14.4% vs 10%) (P < 0.001). In addition, IBD patients had less alcohol abuse (2.3% vs 3.4%), obesity (6% vs 6.9%) and renal disease (5.8% vs 7.2%) (P < 0.001 for all). However, IBD patients were more likely to smoke (12.9% vs 9.5%) and have thyroid disease (8.8% vs 8.2%) (P < 0.001 for all). Using Multivariate logistic regression, and after adjusting for potential confounding factors, IBD was a statistically significant risk factor for osteoporosis (Odds Ratio [OR], 1.869, 95% confidence interval [CI], 1.843-1.895, P < 0.001) compared with patients without IBD. Conclusion: IBD patients are at significant risk to develop osteoporosis. Hence, early screening for osteoporosis and appropriate treatment is essential to prevent fractures in IBD patients.