Details

Autor(en) / Beteiligte

• Sindhu, M.
• Kalaivani, P.
• Dallemer, F.
• Prabhakaran, R.

Titel

Coumarine based Cu(II) complex as chemosensor for selective detection of l-threonine and l-asparagine

Ist Teil von

• Inorganica Chimica Acta, 2021-10, Vol.526, p.120525, Article 120525

Ort / Verlag

Amsterdam: Elsevier B.V

Erscheinungsjahr

2021

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• [Display omitted] •3-AcetCuCl, a chemo sensor probe was prepared and characterised.•Amino acid sensing studies were done by using various l-aminoacids.•Highly selective sensing of l-Asparagine and l-Threonine were done by the probe.•The antiproliferative activity was evaluated against A549 and HT-29 cell lines.•Assay on HEK cell lines showed that the compounds were non-toxic to those cells. A new probe [3-AcetCuCl] (where 3-Acet = 3-acetylcoumarine-4(N)-ethylthiosemicarbazone) has been designed and synthesized and it acts a selective and sensitive fluorescent “on–off” chemosensor for l-asparagine and l-threonine. The cytotoxicity of the probe and sensed compounds were studied against human lung cancer cell line (A549) and human colon cell line (HT-29) in which l-asparagine bounded probe showed better activity in both the cell lines than l-threonine bounded probe.