Details

Autor(en) / Beteiligte

• Zhang, Xin‐Ke
• Miao, Xiao‐Yu
• Jiang, Hui‐Ru
• Ge, Fei
• Sun, Jia‐Chen
• Zhang, Rui‐Ying
• Ouyang, Qin
• Fan, Wei‐Yu
• Zhu, Yan‐Ping
• Sun, Yuan‐Yuan

Titel

Iodine‐Promoted Synthesis of Dipyrazolo/Diuracil‐Fused Pyridines and o‐Amino Diheteroaryl ketones via Oxidative Domino Annulation of 2/4‐Methylazaarenes

Ist Teil von

• Advanced synthesis & catalysis, 2021-10, Vol.363 (19), p.4632-4638

Ort / Verlag

Heidelberg: Wiley Subscription Services, Inc

Erscheinungsjahr

2021

Quelle

Wiley Online Library

Beschreibungen/Notizen

• The iodine‐promoted oxidative domino annulation and carbonylation process has been developed for the synthesis of biologically important azaarene‐substituted bis‐pyrazolo[3,4‐b:4′,3′‐e]pyridines (BPPs), diuracilpyridines and o‐amino diheteroaryl ketones. The domino procedure proceeded with easily available methyl azaarenes, 5‐aminouracils and substituted 5‐aminopyrazoles. This protocol is a simple and metal‐free approach which exhibits high functional group compatibility and broad substrates scope. Moreover, this transformation can be applied for the preparation of dipyrazolo/diuracil‐fused pyridines on a gram scale.