Details

Autor(en) / Beteiligte

• Hu, Yongzhi
• Ma, Xinhua
• Hou, Huiqing
• Sun, Weiming
• Tu, Shuqing
• Wu, Mei
• Lin, Rongkun
• Xu, Xiuzhi
• Ke, Fang

Titel

Electrochemical oxidative synthesis of 2-benzoylquinazolin-4(3 H )-one via C(sp 3 )–H amination under metal-free conditions

Ist Teil von

• Catalysis science & technology, 2021-10, Vol.11 (19), p.6374-6379

Ort / Verlag

Cambridge: Royal Society of Chemistry

Erscheinungsjahr

2021

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• An electrochemically induced C(sp 3 )–H amination of 2-aminobenzamides with ketones using TBAI as a catalyst was developed, and provided 2-benzoylquinazolin-4(3 H )-ones under metal-free conditions. The reaction proceeded using the relatively low-toxicity methanol as the solvent, employed molecular oxygen as the ideal green oxidant in a simple undivided cell, and exhibited high atom economy. The mechanism of this C(sp 3 )–H amination strategy was concluded to involve generation of an acetophenone radical, and its easy further oxidation to form 2-oxo-2-phenylacetaldehyde.