Details

Autor(en) / Beteiligte

• Vasudevan, N
• Aka, Ehu C
• Barré, Elvina
• Wimmer, Eric
• Cortés-Borda, Daniel
• Giraudeau, Patrick
• Farjon, Jonathan
• Rodriguez-Zubiri, Mireia
• François-Xavier Felpin

Titel

Development of a continuous flow synthesis of FGIN-1-27 enabled by in-line 19F NMR analyses and optimization algorithms

Ist Teil von

• Reaction chemistry & engineering, 2021-01, Vol.6 (10), p.1983-1992

Ort / Verlag

Cambridge: Royal Society of Chemistry

Erscheinungsjahr

2021

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A straightforward continuous flow synthesis of FGIN-1-27, a compound with potent anxiolytic effects, is described from inexpensive and commercially available starting materials. The four-step synthesis includes the direct C–H arylation of an indole with an arenediazonium salt. The continuous flow route was developed thanks to the use of enabling technologies such as real-time in-line benchtop 19F NMR analysis and an optimization algorithm assisting the decision-making process. These enabling technologies increase the process safety and minimize the number of experiments required in optimization campaigns.