Details

Autor(en) / Beteiligte

• Jimenez Castro, Pablo D

Titel

Biology, Epidemiology and Genetics of Multiple Drug Resistance in the Canine Hookworm (Ancylostoma caninum)

Ort / Verlag

ProQuest Dissertations & Theses

Erscheinungsjahr

2021

Quelle

ProQuest Dissertations & Theses A&I

Beschreibungen/Notizen

• There have been increasing reports of Ancylostoma caninum infections that do not clear after multiple treatments in different dog breeds in the United States over the past few years. The cause of the lack of clearance of these infections in the majority of cases was determined to be due to anthelmintic resistant isolates of A. caninum. The emergence of this resistance in dogs in the US warranted investigating several epidemiological. To start, an extensive literature review was performed that described the natural history of A. caninum including the biology of the parasite, history of the disease, and taxonomy and life cycle of the nematode, among other topics. The review also provided a history of anthelmintic resistance in general, as well as focusing in this parasite. In the first research section, we attempted to diagnose and describe for the first time cases of multiple drug resistance (MDR) in A. caninum to all the major drug classes used for the treatment of hookworms of dogs in the US. The second study attempted to evaluate the efficacy of a product registered in Europe as well as three other anthelmintic products commonly used for the treatment of canine hookworms registered in the US, against a MDR isolate of A. caninum, Worthy 4.1F3P. The third study used the deep amplicon sequencing assay developed for the first study to study the molecular epidemiology of these resistant isolates in the canine population across the US to be able to provide insights with regards to the origin(s) and spread of this resistance.