Details

Autor(en) / Beteiligte

• Ojeda, M L
• Romero-Herrera, I
• Martínez-López, I
• Carreras, O
• Nogales, F

Titel

SELENIUM IN THE KIDNEY OF LACTATING DAMS WITH METABOLIC SINDROME

Ist Teil von

• Annals of nutrition and metabolism, 2020-01, Vol.76, p.188

Ort / Verlag

Basel: S. Karger AG

Erscheinungsjahr

2020

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Introduction: maternal Metabolic Syndrome (MS) during lactation causes cardiometabolic changes related to Se homeostasis and its antioxidant selenoproteins such as Glutathione Peroxidase (GPx) in the heart. Objective: to analyze renal Se deposits and GPx activity, as well as renal oxidation in lactating mothers with MS, analyzing its repercussion on renal functionality. Methods: two groups of lactating mother wistar rats were used: control (base diet: 0.1 ppm Se) and SM (diet rich in fructose (65%) and 0.1 ppm Se). At the end of lactation (21 d postpartum) Se levels in urine, blood and kidney were measured by graphite furnace atomic spectrophotometry. Renal GPX activity and lipid oxidation were determined by spectrophotometry. To calculate creatinine clearance (Cl), and the relative Cl of Se, serum and urine creatinine were determined by ELISA. Blood pressure was measured by the tail occlusion technique. Results: MS dams ingested less Se in diet and clarified it more by urine, presenting less Se in serum. Renal deposits of Se were increased along with GPx activity; however, lipid peroxidation appeared. Creatinine Cl was increased, indicating an increase in filtration, accompanied by increased blood pressure. Conclusions: MS in mothers during lactation causes profound changes in the body redistribution of Se; increasing it in kidney, probably to avoid oxidative stress. However, this deviation of Se is not enough because there is lipid oxidation, an increase in filtration and in blood pressure. Due to this Se deficiency, we propose its supplementation to avoid renal oxidative damage in lactating mothers with MS, since it could improve renal function and avoid future maternal cardiovascular diseases.