Cancer letters, 2021-10, Vol.518, p.256
2021
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- Autor(en) / Beteiligte
- Titel
- Decoding m 6 A mRNA methylation by reader proteins in cancer
- Ist Teil von
- Cancer letters, 2021-10, Vol.518, p.256
- Ort / Verlag
- Ireland: Elsevier Limited
- Erscheinungsjahr
- 2021
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- N -methyladenosine (m A), the most prevalent internal modification in eukaryotic mRNAs, regulates gene expression at the post-transcriptional level. The reader proteins of m A, mainly YTH domain-containing proteins, specifically recognize m A-modified mRNAs and regulate their metabolism. Recent studies have highlighted essential roles of m A readers in the initiation and development of human cancers. In this review, we summarize recent findings about the biological functions of YTH domain proteins in cancers, the underlying mechanisms, and clinical implications. Gene expression reprogramming by dysregulated m A reader proteins offers potential targets for cancer treatment, while targeted m A editors and readers provide tools to manipulate m A metabolism in cancers.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0304-3835eISSN: 1872-7980DOI: 10.1016/j.canlet.2021.07.047Titel-ID: cdi_proquest_journals_2558081345
- Format
- –
- Schlagworte
- Adenosine, Adenosine - analogs & derivatives, Adenosine - genetics, Animals, Biomarkers, Colorectal cancer, Gene expression, Gene Expression - genetics, Humans, Lung cancer, Metabolism, Methylation, N6-methyladenosine, Neoplasms - genetics, Ovarian cancer, Pathogenesis, Post-transcription, Prostate cancer, Protein Domains - genetics, RNA Processing, Post-Transcriptional - genetics, RNA, Messenger - genetics, RNA-protein interactions