Details

Autor(en) / Beteiligte

• Wu, Tingjuan
• Li, Anfeng
• Chen, Kexin
• Peng, Xingxing
• Zhang, Jing
• Jiang, Mou
• Chen, Shizhen
• Zheng, Xing
• Zhou, Xin
• Jiang, Zhong-Xing

Titel

Perfluoro- tert -butanol: a cornerstone for high performance fluorine-19 magnetic resonance imaging

Ist Teil von

• Chemical communications (Cambridge, England), 2021-08, Vol.57 (63), p.7743-7757

Ort / Verlag

Cambridge: Royal Society of Chemistry

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• As a versatile quantification and tracking technology, 19 F magnetic resonance imaging ( 19 F MRI) provides quantitative “hot-spot” images without ionizing radiation, tissue depth limit, and background interference. However, the lack of suitable imaging agents severely hampers its clinical application. First, because the 19 F signals are solely originated from imaging agents, the relatively low sensitivity of MRI technology requires high local 19 F concentrations to generate images, which are often beyond the reach of many 19 F MRI agents. Second, the peculiar physicochemical properties of many fluorinated compounds usually lead to low 19 F signal intensity, tedious formulation, severe organ retention, etc. Therefore, the development of 19 F MRI agents with high sensitivity and with suitable physicochemical and biological properties is of great importance. To this end, perfluoro- tert -butanol ( PFTB ), containing nine equivalent 19 F and a modifiable hydroxyl group, has outperformed most perfluorocarbons as a valuable building block for high performance 19 F MRI agents. Herein, we summarize the development and application of PFTB-based 19 F MRI agents and analyze the strategies to improve their sensitivity and physicochemical and biological properties. In the context of PFC-based 19 F MRI agents, we also discuss the challenges and prospects of PFTB-based 19 F MRI agents.