Details

Autor(en) / Beteiligte

• Ngamcherdtrakul, Worapol
• Reda, Moataz
• Nelson, Molly A.
• Wang, Ruijie
• Zaidan, Husam Y.
• Bejan, Daniel S.
• Hoang, Ngoc Ha
• Lane, Ryan S.
• Luoh, Shiuh‐Wen
• Leachman, Sancy A.
• Mills, Gordon B.
• Gray, Joe W.
• Lund, Amanda W.
• Yantasee, Wassana

Titel

Tumor Therapy: In Situ Tumor Vaccination with Nanoparticle Co‐Delivering CpG and STAT3 siRNA to Effectively Induce Whole‐Body Antitumor Immune Response (Adv. Mater. 31/2021)

Ist Teil von

• Advanced materials (Weinheim), 2021-08, Vol.33 (31), p.n/a

Ort / Verlag

Weinheim: Wiley Subscription Services, Inc

Erscheinungsjahr

2021

Quelle

Wiley Blackwell Single Titles

Beschreibungen/Notizen

• In article number 2100628, Wassana Yantasee and co‐workers investigate how Augmenting Immune Response and Inhibiting Suppressive Environment of tumors‐02 (AIRISE‐02) activates an antitumor immune response. AIRISE‐02 is a nanoparticle co‐delivering STAT3 siRNA and CpG intratumorally, utilizing local tumor antigens to train the immune system to kill cancer throughout the body. AIRISE‐02 shows strong efficacy in various tumor models, and favorable safety in mice and monkeys.