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The objective of this study is to build a numerical model which combine with experimental design method as a probabilistic approach to overcome the uncertainty parameters of reservoir so that can be obtained more valid assessment result. A Plackett-Burmann design method was used to minimize experimental simulation run into 12 experiments by investigating six uncertainty parameters with two degrees level. This process assesses the impact of evaluated parameters affecting resources and interacting between these parameters. This methodology have been successfully estimated the maximum resources with polynomial function covering the entire range of possible values of important reservoir parameters.