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Of all activities related to carbon dioxide generation in Lampung University, vehicle exhaust is a main source of anthropogenic carbon dioxide (CO2). Carbon dioxide (CO2) may trap the earth's heat which worsens the climate change. As For the physical condition of humans, high concentration of CO2 exposure may cause death, unconsciousness, convulsions and fetus damage. Even in lower concentration, CO2 exposure can cause hyperventilation, vision damage, lung congestion, central nervous system injury, and other health problems. A case survey was conducted to measure CO2 emission based on two type of vehicles; private car and motorcycle to obtain the number of vehicle entry per gate. A mathematical model was also used to estimate CO2 production. Several factors such as fuel consumption, emission factor, and number of running per day (distance) were used as inputs. CO2 emission in the next five years was also estimated using the same method by previously extrapolated the earliest 5 years population data of Lampung University. The result shows that motorcycles are responsible for 1.636 ton of CO2 emission or approximately 55% of the total CO2 emission in Lampung University. Meanwhile, cars contribute to 1.34 ton of CO2 emission or approximately 45% of the total CO2 emission. It was also estimated that Lampung University would have an increase in vehicle number by 7.81%.