Details

Autor(en) / Beteiligte

• Liu, Huiyun
• Tian, Yingrui
• Sui, Jianliang
• Wang, Menglei
• Yin, Miaomiao
• Wang, Zhen

Titel

Application of UPLC-QTOF-MS Technology in Quality Stability Evaluation of Moluodan Concentrated Pills

Ist Teil von

• Medicinal plant, 2021-04, Vol.12 (2), p.85-94

Ort / Verlag

Cranston: Wu Chu (USA-China) Science and Culture Media Corporation

Erscheinungsjahr

2021

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Key words Moluodan concentrated pill, Ultra performance liquid chromatography-quadrupole time-of-flight mass spectrometry, Quality stability, Principal component analysis 1 Introduction The active ingredient of Chinese patent medicines are complex, and the material basis of efficacy is not clear. The types and quantities of chemical components contained in traditional Chinese medicine can more comprehensively reflect the inherent quality of traditional Chinese medicine%6-7]. [...]by comparing the types and quantities of chemical components contained in diferent batches of samples' the quality stability of the samples can be directly reflected. In this study' ultra performance liquid chromatography-quadrupole time-of-flight mass spectrometry ( UPLC-QTOF-MS) technology was used to analyze the chemical components contained in Moluodan concentrated pils' and combined with PCA' the quality stabilit of the samples was evaluated. 2 Materials and methods 2.1 Materials 2.1.1 Instrument and equipment. 7% , respectively, both less than 20% , showing that the data quality of thii experiment i high, and the system is relatively stable. 3.2 UPLC-QTOF-MS detection results of Moluodan concentrated pills and quality evaluation of different batches of samples 3.2.1 Total ion current chromatogram of Moluodan concentrated pils. Because the QC samples were prepared with the test solutions of the 10 diferent batches of Moluodan concentrated pills, in order to eliminate the difference in chemical composition of different batches of samples, in the qualitative analysis of the chemical components contained in Moluodan concentrated pills, the QC samples were selected as the research object.