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Biotin-Yellow a biotin guided NIR turn-on fluorescent probe for cancer targeted diagnosis
Ist Teil von
Sensors and actuators. B, Chemical, 2021-06, Vol.337, p.129807, Article 129807
Ort / Verlag
Lausanne: Elsevier B.V
Erscheinungsjahr
2021
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
[Display omitted]
•The tumor-targeting and biothiol activatable fluorescent probe Biotin-Yellow was developed.•Biotin-Yellow is non-toxic, it can effectively recognize and discriminate cancer cells from embryonic fibroblasts cells.•Biotin-Yellow has unprecedented turn-on near-infrared fluorescence and colorimetric properties.•Biotin-Yellow can be employed for real-time bioimaging tracking of biothiols in cancer cells.•The efficacy and biothiol responsiveness of Biotin-Yellow was validated in vivo in zebrafish and mice.
A dicyanomethylene-4H-pyran based tumor-targeting and biothiol activatable fluorescent and colorimetric probe, named Biotin-Yellow, has been developed with unprecedented turn-on near-infrared fluorescence properties. Biotin-Yellow is non-toxic and can effectively recognize and discriminate human lung adenocarcinoma cells and urothelial (bladder) carcinoma cells from embryonic kidney cells and embryonic fibroblasts. Biotin-Yellow can also be employed for real-time bioimaging tracking of upregulated biothiol activity in cancer cells. The efficacy and biothiol responsiveness of Biotin-Yellow was further validated in vivo in zebrafish and mice xenografts.