Details

Autor(en) / Beteiligte

• Diamantis, Dimitrios A.
• Agalou, Adamantia
• Chatziathanasiadou, Maria V.
• Markopoulos, Georgios S.
• Bellou, Sofia
• Kanaki, Zoi
• Crook, Timothy
• Syed, Nelofer
• Rampias, Theodoros
• Klinakis, Apostolos
• Kolettas, Evangelos
• Beis, Dimitris
• Tzakos, Andreas G.

Titel

Biotin-Yellow a biotin guided NIR turn-on fluorescent probe for cancer targeted diagnosis

Ist Teil von

• Sensors and actuators. B, Chemical, 2021-06, Vol.337, p.129807, Article 129807

Ort / Verlag

Lausanne: Elsevier B.V

Erscheinungsjahr

2021

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• [Display omitted] •The tumor-targeting and biothiol activatable fluorescent probe Biotin-Yellow was developed.•Biotin-Yellow is non-toxic, it can effectively recognize and discriminate cancer cells from embryonic fibroblasts cells.•Biotin-Yellow has unprecedented turn-on near-infrared fluorescence and colorimetric properties.•Biotin-Yellow can be employed for real-time bioimaging tracking of biothiols in cancer cells.•The efficacy and biothiol responsiveness of Biotin-Yellow was validated in vivo in zebrafish and mice. A dicyanomethylene-4H-pyran based tumor-targeting and biothiol activatable fluorescent and colorimetric probe, named Biotin-Yellow, has been developed with unprecedented turn-on near-infrared fluorescence properties. Biotin-Yellow is non-toxic and can effectively recognize and discriminate human lung adenocarcinoma cells and urothelial (bladder) carcinoma cells from embryonic kidney cells and embryonic fibroblasts. Biotin-Yellow can also be employed for real-time bioimaging tracking of upregulated biothiol activity in cancer cells. The efficacy and biothiol responsiveness of Biotin-Yellow was further validated in vivo in zebrafish and mice xenografts.