Details

Autor(en) / Beteiligte

• Reinholdt, Kristian
• Kjær, Susanne Krüger
• Guleria, Sonia
• Frederiksen, Kirsten
• Mellemkjær, Lene
• Munk, Christian
• Jensen, Allan

Titel

38 Risk of endometrial cancer among women with benign ovarian tumors – a danish nationwide cohort study

Ist Teil von

• International journal of gynecological cancer, 2020-12, Vol.30 (Suppl 4), p.A27-A28

Ort / Verlag

Oxford: BMJ Publishing Group LTD

Erscheinungsjahr

2020

Beschreibungen/Notizen

• Introduction/BackgroundThe few studies investigating a potential association between benign ovarian tumors and endometrial cancer have been inconclusive. Using data from a large Danish register-based cohort study, we assessed the overall and type-specific risk of endometrial cancer among women with a benign ovarian tumor.MethodologyWe identified all Danish women diagnosed with a benign ovarian tumor during 1978–2016 in the Danish National Patient Register (n = 149,807). The study population was followed for subsequent development of endometrial cancer by linkage to the Danish Cancer Register and standardized incidence ratios (SIRs) with corresponding 95% confidence intervals (CIs) were calculated after correction for hysterectomy.ResultsWomen with benign ovarian tumors had a decreased incidence of endometrial cancer (SIR = 0.74, 95% CI: 0.68–0.81) compared with women in the general Danish female population. Both solid benign ovarian tumors (SIR = 0.79, 95% CI 0.70–0.88) and cystic benign ovarian tumors (SIR = 0.68, 95% CI 0.58–0.78) were associated with decreased incidences of endometrial cancer. Likewise, women with benign ovarian tumors had decreased incidences of both type I and type II endometrial cancer. The incidence of endometrial cancer was decreased to virtually the same magnitude irrespective of the age at diagnosis of a benign ovarian tumor and the reduction persisted for up to 20+ years after the ovarian tumor diagnosis.ConclusionThe risk of endometrial cancer was decreased beyond the first year after a benign ovarian tumor and the decrease persisted for 20 or more years. The possible underlying mechanisms are not known and should be investigated further.DisclosuresNone.