Details

Autor(en) / Beteiligte

• Plentz, TBS
• Dias, LF
• Santos, DZ
• Silva, MLM
• Torres, JCC
• Vale, DB
• Teixeira, J

Titel

424 Large retrospective cohort of uterine sarcomas: poor survival of carcinosarcomas and leiomyosarcomas

Ist Teil von

• International journal of gynecological cancer, 2019-09, Vol.29 (Suppl 3), p.A176-A176

Ort / Verlag

Oxford: by the International Gynecologic Cancer Society and the European Society of Gynaecological Oncology

Erscheinungsjahr

2019

Beschreibungen/Notizen

• ObjectivesTo describe the diagnosis and outcomes of 122 cases of women with uterine sarcomas from a university hospital (Unicamp/Brazil).MethodsA retrospective cohort from 2001–2016 cases. Variables were described by proportions and analysed by Chi-Square or Fisher tests and survival by Kaplan-Meier survival curves and log-rank test.ResultsOf the 122 sarcoma cases 77% were postmenopausal women, 46.7% were carcinosarcomas (CCS), 22% leiomyosarcomas (LMS), 16% endometrial stromal sarcomas (EES) and 13.9% adenosarcomas (ADS). A high proportion of stage I were find in EES (60%) and ADS (82%). Surgery was the first treatment in 78% with 79% performing adjuvant therapy and 22.1% were not able surgery, mainly in CCS (32%). Complete response was observed in 55 cases, and 20 relapsed (36%) at follow-up, 90% at three years. Overall survival was 76% at 12 months and 33% at 5 years, better for EES and ADS than for CCS and LMS (P=0.003). At the end of the study, 25% remained alive without disease and 57% had died from the disease, 78% of LMS and 61% of CCS (P=0.005).ConclusionsIn this large cohort of uterine sarcomas, surgery was the first treatment in 78% of cases and overall 5-years survival was only 33%. Women with CCS and LMS showed a worse prognosis than women with EES and ADS.