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Metal‐Free Synthesis of Alkenylazaarenes and 2‐Aminoquinolines through Base‐Mediated Aerobic Oxidative Dehydrogenation of Benzyl Alcohols
Ist Teil von
European journal of organic chemistry, 2021-05, Vol.2021 (19), p.2746-2751
Ort / Verlag
Weinheim: Wiley Subscription Services, Inc
Erscheinungsjahr
2021
Link zum Volltext
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
A metal‐free, base‐mediated, and atom‐efficient oxidative dehydrogenative coupling of substituted phenylmethanols (benzyl alcohols) with methyl azaarenes or phenylacetonitriles to afford substituted alkenylazaarenes or 2‐aminoquinolines, respectively is described. CsOH.H2O was discovered to be the base of choice for obtaining optimal yields of the title compounds, although the reaction could proceed with KOH as well. The protocol that works efficiently in the presence of air is amenable over broad range of substrates.
A metal‐free, base‐mediated oxidative dehydrogenative coupling of substituted phenylmethanols (benzyl alcohols) with methyl azaarenes or phenylacetonitriles to afford substituted alkenylazaarenes or 2‐aminoquinolines, respectively is presented.