Details

Autor(en) / Beteiligte

• Song, Yudong
• Huang, Hui
• He, Dayong
• Yang, Mei
• Wang, Hao
• Zhang, Hao
• Li, Jiali
• Li, Yongxin
• Wang, Ce

Titel

Gallic Acid/2-Hydroxypropyl-β-cyclodextrin Inclusion Complexes Electrospun Nanofibrous Webs: Fast Dissolution, Improved Aqueous Solubility and Antioxidant Property of Gallic Acid

Ist Teil von

• Chemical research in Chinese universities, 2021-06, Vol.37 (3), p.450-455

Ort / Verlag

Changchun: Jilin University and The Editorial Department of Chemical Research in Chinese Universities

Erscheinungsjahr

2021

Link zum Volltext

Quelle

SpringerLink

Beschreibungen/Notizen

• G allic acid(GA) is a kind of natural polyphenolic compound, but its low aqueous solubility restricts its application in the fields of food and medicine. Cyclodextrin can form inclusion complexes with guest molecules( e.g. , essential oils, food supplements) through cavities with special properties to improve aqueous solubility, thermal stability, and bioavailability of guest molecules. In this research, gallic acid/2-hydroxypropyl- β -cyclodextrin inclusion complexes(GA/2-HP- β -CD/ICs) were formed in a highly concentrated solution of 2-HP- β -CD. Bead-free and uniform nanofibrous webs(GA/2-HP- β -CD/IC-NWs) were produced successfully by electrospun GA/HP- β -CD/IC aqueous solution. The initial molar ratio(GA: 2-HP- β -CD=1:1) of GA/2-HP- β -CD/IC in the solutions was largely maintained in GA/2-HP- β -CD/IC-NW. The aqueous solubility of GA was enhanced and GA/2-HP- β -CD/IC-NW has displayed fast dissolution property. Furthermore, in comparison with GA powder, GA/2-HP- β -CD/IC-NW demonstrated improved antioxidant capacity. The results suggested that GA/2-HP- β -CD/IC-NW have broad application prospects as orally fast dissolution systems for food supplements.