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Bimetallic Al–Cu and Al–Ag nanoparticles were synthesized by electric explosion of wires in an argon atmosphere. The mass ratio of aluminum and the second metal (Me = Cu or Ag) was ~ 90 : 10 and was controlled by the diameter of the dispersed metal wires. Mesoporous AlOOH–Me nanocomposite was obtained by simple oxidation of Al–Me precursors with water at a temperature of 60°С. The kinetic regularities of the oxidation of Al–Me nanoparticles in dilute aqueous suspensions were studied. The effect of the second metal on the structure, morphology, and antibacterial activity of nanocomposites against methicillin-resistant
Staphylococcus aureus
(MRSA) bacteria was studied. It has been shown that the synthesized AlOOH–Me nanocomposites possess high antibacterial activity and are promising and highly efficient antimicrobial agents.