Details

Autor(en) / Beteiligte

• Xia, Chao
• Wang, Dong-Chao
• Qu, Gui-Rong
• Guo, Hai-Ming

Titel

Palladium-catalyzed asymmetric allylic amination of a vinylethylene carbonate with N-heteroaromatics

Ist Teil von

• Organic Chemistry Frontiers, 2021-06, Vol.8 (11), p.2569-2575

Ort / Verlag

London: Royal Society of Chemistry

Erscheinungsjahr

2021

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Highly enantioselective allylation of a vinylethylene carbonate by asymmetric palladium catalysis has been developed for a variety of N-heteroaromatic substrates. The employed procedure allows for the efficient synthesis of various acyclic nucleoside analogs in good yields (up to 96%) and with high enantioselectivities (up to 99%) at the Pd catalyst amount of 0.5 mol%. In addition, these acyclic nucleosides are demonstrated to undergo rapid transformation to a variety of interesting structurally diverse chiral acyclic nucleosides and isonucleosides.