Details

Autor(en) / Beteiligte

• Chinta, Rajarao
• Rohini, P.

Titel

Formulation development of Empagliflozin and Metformin hydrochloride extended release tablets: Optimization of formulation using statistical experimental design

Ist Teil von

• Research journal of pharmacy and technology, 2021-03, Vol.14 (3), p.1201-1208

Ort / Verlag

Raipur: A&V Publications

Erscheinungsjahr

2021

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Despite continued advances in the treatments available for T2DM, glycemic control is frequently suboptimal. Because T2DM is characterized by multiple metabolic abnormalities, current treatment algorithms involving a stepwise approach to the use of combination therapy involving agents with complementary modes of action are frequently necessary. [...]factorial design was selected as DoE.3 Impact of various formulation variables and critical process parameters on extended release part (metformin hydrochloride) were statistically interpreted and significant variables were optimized in our earlier investigation. Sodium CMC 7HF PH (Ashland), HPMC K 100M CR (Dow chemical's), polyethylene oxide Sentry Polyox WSR-303-LEO (Dow chemical's), Carbopol 971P (Lubrizol), Colloidal silicon dioxide aerosil 200 pharma (Evonik), Magnesium Stearate (Peter greven), Lactose spray dried Supertab 11SD (DFE), Microcrystalline cellulose PH112 (FMC), Croscarmellose sodium Ac-Di-Sol (FMC), Hydroxy propyl cellulose klucel LF (Nippon soda) were used as received. [...]found that the concentrations of binder and disintegrant had a significant impact on drug release of IR part.