European journal of immunology, 2021-04, Vol.51 (4), p.995-998
2021
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- Autor(en) / Beteiligte
- Titel
- Musculin is highly enriched in Th17 and IL‐22‐producing ILC3s and restrains pro‐inflammatory cytokines in murine colitis
- Ist Teil von
- European journal of immunology, 2021-04, Vol.51 (4), p.995-998
- Ort / Verlag
- Germany: Wiley Subscription Services, Inc
- Erscheinungsjahr
- 2021
- Quelle
- Wiley-Blackwell Journals
- Beschreibungen/Notizen
- Transcription suppressor Musculin (MSC) is enriched in pro‐inflammatory Th17 and IL‐22‐producing ILC3s. While MSC+/+ mice survived DSS‐induced colitis, MSC−/− mice showed elevated pro‐inflammatory cytokines with severer pathology, reduced body weight, and earlier death. Reversal of colitis symptoms in MSC−/− mice by IL‐22 antagonism suggests the existence of MSC:IL‐22 regulatory axis.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0014-2980eISSN: 1521-4141DOI: 10.1002/eji.202048573Titel-ID: cdi_proquest_journals_2513076961
- Format
- –
- Schlagworte
- Animals, Basic Helix-Loop-Helix Transcription Factors - genetics, Basic Helix-Loop-Helix Transcription Factors - immunology, Basic Helix-Loop-Helix Transcription Factors - metabolism, Body weight, Colitis, Colitis - chemically induced, Colitis - genetics, Colitis - immunology, Cytokines, Cytokines - immunology, Cytokines - metabolism, Dextran Sulfate, Helper cells, ILC3, IL‐22, Immunity, Innate - immunology, Inflammation, Inflammation Mediators - immunology, Inflammation Mediators - metabolism, Inflammatory bowel disease, Interleukin-17 - immunology, Interleukin-17 - metabolism, Interleukin-22, Interleukins - genetics, Interleukins - immunology, Interleukins - metabolism, Lymphocytes - immunology, Lymphocytes - metabolism, Lymphocytes T, Mice, Mice, Inbred C57BL, Mice, Knockout, Mice, Transgenic, Musculin, Th17, Th17 Cells - immunology, Th17 Cells - metabolism, Transcription, Transcription factor