Anticancer research, 2021-04, Vol.41 (4), p.2053-2058
2021
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- Autor(en) / Beteiligte
- Titel
- Prognostic Role for CYFRA 21-1 in Patients With Advanced-stage NSCLC Treated With Bevacizumab Plus Chemotherapy
- Ist Teil von
- Anticancer research, 2021-04, Vol.41 (4), p.2053-2058
- Ort / Verlag
- Greece: International Institute of Anticancer Research
- Erscheinungsjahr
- 2021
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- To investigate potential associations between selected oncomarkers [carcinoembryonic antigen (CEA), C-terminus of cytokeratin 19 (CYFRA 21-1, CYFRA), and squamous cell carcinoma antigen (SCC)] and outcomes in patients with NSCLC treated with bevacizumab plus chemotherapy. We retrospectively analysed 105 patients with NSCLC from the Czech TULUNG registry treated at University Hospital in Pilsen with bevacizumab plus chemotherapy. Response to therapy was tested by Fisher's exact test. Survival statistics were evaluated using the Kaplan-Meier method and Cox analysis. Only normal values of CYFRA (not CEA or SCC) were associated with significantly better overall and progression-free survival in univariate analysis. We also observed a trend for a better disease control rate in patients with normal levels of CYFRA. In a multivariate Cox model, only CYFRA was associated with significantly better overall but not progression-free survival. In our retrospective study, we point out the possibility of using CYFRA as a prognostic marker in patients with NSCLC treated with chemotherapy plus bevacizumab.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0250-7005eISSN: 1791-7530DOI: 10.21873/anticanres.14974Titel-ID: cdi_proquest_journals_2511382921
- Format
- –
- Schlagworte
- Aged, Antigens, Antigens, Neoplasm - analysis, Antigens, Neoplasm - blood, Antigens, Neoplasm - physiology, Antineoplastic Agents - therapeutic use, Bevacizumab, Bevacizumab - administration & dosage, Bevacizumab - adverse effects, Biomarkers, Pharmacological - analysis, Biomarkers, Tumor - analysis, Biomarkers, Tumor - physiology, C-Terminus, Carcinoembryonic antigen, Carcinoembryonic Antigen - analysis, Carcinoembryonic Antigen - blood, Carcinoma, Non-Small-Cell Lung - diagnosis, Carcinoma, Non-Small-Cell Lung - drug therapy, Carcinoma, Non-Small-Cell Lung - mortality, Carcinoma, Non-Small-Cell Lung - pathology, Chemotherapy, Cytokeratin, Disease control, Disease Progression, Female, Humans, Keratin-19 - analysis, Keratin-19 - blood, Keratin-19 - physiology, Lung cancer, Lung Neoplasms - diagnosis, Lung Neoplasms - drug therapy, Lung Neoplasms - mortality, Lung Neoplasms - pathology, Male, Middle Aged, Neoplasm Staging, Non-small cell lung carcinoma, Predictive Value of Tests, Prognosis, Retrospective Studies, Serpins - analysis, Serpins - blood, Squamous cell carcinoma, Statistical analysis, Statistical tests, Survival, Treatment Outcome