Details

Autor(en) / Beteiligte

• Szklarzewicz, Janusz
• Jurowska, Anna
• Hodorowicz, Maciej
• Kazek, Grzegorz
• Głuch-Lutwin, Monika
• Sapa, Jacek

Titel

Ligand role on insulin-mimetic properties of vanadium complexes. Structural and biological studies

Ist Teil von

• Inorganica Chimica Acta, 2021-02, Vol.516, p.120135, Article 120135

Ort / Verlag

Amsterdam: Elsevier B.V

Erscheinungsjahr

2021

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The structural, physicochemical and biological study on vanadium(IV and V) Schiff base complexes in which the relationship between phosphatase inhibition and cytotoxicity of the compounds and the key role of organic ligands in enhancing biological activity of vanadium complexes was discussed. The biological activity of the vanadium complexes can be related to their stability in the studied biological systems. [Display omitted] •16 vanadium(IV) and (V) complexes with ONO Schiff base ligands were synthesized.•The crystal structures, stability and biological activity of complexes were discussed.•The role of ligands in enhancing biological activity of V(IV/V) complexes was discussed. The syntheses of 16 vanadium(IV and V) complexes with ONO tridentate Schiff base ligands are described. The vanadium(IV) compounds were synthesized with 1,10-phenantroline as a co-ligand. In the case of five complexes of vanadium(V), the solvent molecule in form of ethanol or ethoxy ligand fill the coordination sphere of V(V) to six. In the crystal structure of selected complexes the mixture of isomers in 1:1 ratio in the unit cell is observed as the ligand is not symmetrical and forms both 5- and 6-membered rings in complex. All complexes were characterized also by elemental analysis, IR and UV–Vis spectroscopy, magnetic and cyclic voltammetry measurements. The stability of the complexes in DMSO-H2O mixture was performed at pH = 7.0 and 2.0. The relationship between phosphatase inhibition and cytotoxicity of the compounds and the key role of organic ligands in enhancing biological activity of vanadium complexes was also discussed.