Details

Autor(en) / Beteiligte

• Carey, Ryan M.
• Shimunov, David
• Weinstein, Gregory S.
• Cannady, Steven B.
• Lukens, John N.
• Lin, Alexander
• Swisher‐McClure, Samuel
• Bauml, Joshua M.
• Aggarwal, Charu
• Cohen, Roger B.
• Newman, Jason G.
• Chalian, Ara A.
• Rassekh, Christopher H.
• Basu, Devraj
• O'Malley, Bert W.
• Rajasekaran, Karthik
• Brody, Robert M.

Titel

Increased rate of recurrence and high rate of salvage in patients with human papillomavirus–associated oropharyngeal squamous cell carcinoma with adverse features treated with primary surgery without recommended adjuvant therapy

Ist Teil von

• Head & neck, 2021-04, Vol.43 (4), p.1128-1141

Ort / Verlag

Hoboken, USA: John Wiley & Sons, Inc

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Wiley Online Library

Beschreibungen/Notizen

• Background Some patients with human papillomavirus (HPV)–associated oropharyngeal squamous cell carcinoma (OPSCC) do not receive guideline‐recommended postoperative radiation therapy (PORT) following primary transoral robotic surgery (TORS). Methods Three‐hundred and sixty‐four patients with treatment‐naïve, HPV‐associated OPSCC were recommended to receive PORT based on clinicopathological features following TORS. Patients were stratified based on if they received PORT. Oncologic outcomes were compared. Results The 3‐year locoregional failure (LRF) was 32% in patients who did not receive PORT and 4% in patients who received PORT (P < .001). Despite increased LRF, avoiding PORT was not associated with increased 3‐year distant metastasis rates (8% vs 4%, P = .56) or worse 3‐year survival (95% vs 98%, P = .34). Recurrences in the surgery alone cohort varied between local and regional sites and were often successfully salvaged. Conclusions Patients with HPV‐associated OPSCC who do not receive indicated PORT have an increased risk of LRF but similar survival due to high salvage rates.