Details

Autor(en) / Beteiligte

• Liu, J
• Ramakrishnan, S
• Laxminarayan, S
• Cashmere, JD
• McNamee, RL
• Rode, N
• Germain, A
• Reifman, J

Titel

1082 REPRODUCIBLE EEG SIGNALS DISCRIMINATE COMBAT VETERANS WITH PTSD

Ist Teil von

• Sleep (New York, N.Y.), 2017-04, Vol.40 (suppl_1), p.A403-A403

Ort / Verlag

US: Oxford University Press

Erscheinungsjahr

2017

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Abstract Introduction: Putative quantitative electroencephalography (EEG) markers of post-traumatic stress disorder (PTSD) during sleep show poor inter-night reproducibility. This raises concerns about their clinical utility for diagnosis and personalized treatment. To address this challenge, we investigated approaches to improve inter-night stability and discriminatory power of EEG spectral features. Methods: We obtained bilateral 10-channel EEG recordings (frontal, central, temporal, parietal, and occipital) from 66 combat veterans (50 with PTSD) during two nights of sleep, separated in most cases by less than 30 days (82%). We computed the absolute EEG spectral power across 10 EEG channels, 5 sleep stages and nocturnal wakefulness, and 6 frequency bands (360 features). We subsequently normalized the features by calculating the spectral power ratios across different sleep stages and nocturnal wakefulness (900 features). For each feature, we computed the correlation coefficient (Spearman’s ρ) between nights as a measure of inter-night stability, and the effect size (Hedges’ g) as a measure of discriminatory power (PTSD vs. healthy groups). Results: None of the absolute EEG spectral features yielded g > 0.5 across nights, despite g exceeding 0.5 for 5 and 21 features for the first and second nights, respectively. In contrast, 34 power-ratio features yielded g > 0.5 and ρ > 0.5 across nights. Most of these features exhibited elevated delta (frontal), theta (frontal), alpha (occipital), and beta (frontal and central) powers during slow-wave sleep relative to wakefulness and lighter sleep stages among PTSD subjects compared with healthy subjects. Conclusion: Normalization of EEG spectral powers across sleep stages yielded a set of features that were both stable and discriminatory across nights. These potential PTSD markers support the hypothesis that both central arousal and sleep pressure remain higher across sleep stages in subjects with PTSD compared to healthy subjects. Support (If Any): The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the US Army or of the US Department of Defense. This abstract has been approved for public release with unlimited distribution.