Details

Autor(en) / Beteiligte

• Mu, Li-Min
• Liu, Lei
• Liu, Rui
• Duan, Jia-Lun
• Ma, Shuang
• Li, Xue-Qi
• Cui, Yi-Nuo
• Su, Zhan-Bo
• Zhang, Xiao
• Hu, Jian-Xing
• Xie, Ying
• Zheng, Ying
• Lu, Wan-Liang

Titel

Development of functional dendrisomes based on a single molecule of polyesterbenzylether dendrimer and their application in cancer stem cell therapy

Ist Teil von

• NPG Asia materials, 2019-07, Vol.11 (1), p.1-16, Article 34

Ort / Verlag

Tokyo: Nature Publishing Group

Erscheinungsjahr

2019

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Abstract The differentiation therapy of breast cancer stem cells (CSCs) represents a significant strategy to treat cancer, but inefficient delivery to CSCs hinders the efficacy of differentiation agents. In this work, we report a type of functional dendrisomes constructed by the synthesized amphiphilic dendrimers, which enhance cellular uptake by breast CSCs, differentiate breast CSCs by carrying all-trans retinoic acid (ATRA), and increase the anticancer efficacy by carrying ATRA and docetaxel (DTX) in vitro and in breast cancer-bearing mice. The study further reveals the mechanism of cellular uptake by breast CSCs and uncovers the differentiation mechanism by analyzing relevant signal molecules, transcription factors, and cell cycle-associated signaling pathways during differentiation therapy in breast CSCs. Hence, this study offers a novel type of functional dendrisomes for differentiation therapy of breast CSCs and has significant clinical implications.