Details

Autor(en) / Beteiligte

• Graf, Marion
• Böttcher, Hans‐Christian
• Sünkel, Karlheinz
• Thavalingam, Sugina
• Metzler‐Nolte, Nils
• Czerwieniec, Rafał

Titel

Bis‐cyclometalated Iridium Complexes Containing Modified Phenanthroline Ligands and Evaluation of their Cytotoxic Activities

Ist Teil von

• Zeitschrift für anorganische und allgemeine Chemie (1950), 2021-02, Vol.647 (4), p.306-311

Ort / Verlag

Weinheim: Wiley Subscription Services, Inc

Erscheinungsjahr

2021

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The synthesis and characterization of new bis‐cyclometalated complex salts [Ir(ptpy)2(Lphen)]PF6 with Lphen = 2,9‐dimethyl‐4,7‐bis(pentyloxy)‐1,10‐phenanthroline (1) and Lphen = 2,9‐dimethyl‐4,7‐bis(2‐ethoxyethoxyl)‐1,10‐phenanthroline (2) are described. Compounds 1 and 2 were obtained by the reaction of the corresponding phenanthroline ligands with [{Ir(μ‐Cl)(ptpy)2}2] in a refluxing CH2Cl2/MeOH mixture. The molecular structure of compound 2 was confirmed by single‐crystal X‐ray structure determination. Complex 2 was crystallized from dichloromethane/methanol/iso‐hexane in the monoclinic space group P21/c. The biological activity of both new compounds was examined, and they exhibit significant cytotoxicity against human cancer cell lines with the IC50 values around 2 μM, significantly better than the established anticancer drug cisplatin under identical conditions.