Details

Autor(en) / Beteiligte

• Oberheide, Ansgar
• Arndt, Hans‐Dieter

Titel

Effective C5‐Arylation of Peptide‐Integrated Oxazoles: Almazole D

Ist Teil von

• Advanced synthesis & catalysis, 2021-02, Vol.363 (4), p.1132-1136

Ort / Verlag

Heidelberg: Wiley Subscription Services, Inc

Erscheinungsjahr

2021

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• An efficient functionalization approach of oxazoles by using Pd‐catalyzed cross‐coupling reactions is reported. Oxazolone formation and subsequent sulfamoylation in situ are facilitated by employing N,N‐diethylsulfamoyl imidazolium triflate. Cross‐couplings provide both oxazole‐arenes and oxazole‐heteroarenes and were compatible with sensitive and epimerization‐prone substrates, as exemplified by the total synthesis of the natural product almazole D.