Details

Autor(en) / Beteiligte

• Ouyang, Cheng
• Li, Yongguang
• Rees, Thomas W.
• Liao, Xinxing
• Jia, Jianhua
• Chen, Yu
• Zhang, Xiting
• Ji, Liangnian
• Chao, Hui

Titel

Supramolecular Assembly of An Organoplatinum(II) Complex with Ratiometric Dual Emission for Two‐Photon Bioimaging

Ist Teil von

• Angewandte Chemie International Edition, 2021-02, Vol.60 (8), p.4150-4157

Auflage

International ed. in English

Ort / Verlag

Germany: Wiley Subscription Services, Inc

Erscheinungsjahr

2021

Quelle

MEDLINE

Beschreibungen/Notizen

• The organoplatinum(II) complex [Pt(C^N^N)(Cl)] (C^N^N=5,6‐diphenyl‐2,2′‐bipyridine, Pt1) can assemble into nanoaggregates via π–π stacking and complementary hydrogen bonds, rather than Pt–Pt interactions. Pt1 exhibits ratiometric dual emission, including rare blue emission (λem=445 nm) and assembly‐induced yellow emission (λem=573 nm), under one‐ and two‐photon excitation. Pt1 displays blue emission in cells with an intact membrane due to its low cellular uptake. In cells where the membrane is disrupted, uptake of the complex is increased and at higher concentrations yellow emission is observed. The ratio of yellow to blue emission shows a linear relationship to the loss of cell membrane integrity. Pt1 is, to our knowledge, the first example of an assembly‐induced two‐photon ratiometric dual emission organoplatinum complex. The excellent and unique characteristics of the complex enabled its use for the tracking of cell apoptosis, necrosis, and the inflammation process in zebrafish. An organoplatinum(II) complex exhibits ratiometric dual emission on assembly via π–π stacking. The excellent and unique characteristics of the complex enable the tracking of cell apoptosis, necrosis, and the inflammation process in zebrafish.