Details

Autor(en) / Beteiligte

• Lascano, Sheila
• Chávez-Vásconez, Ricardo
• Muñoz-Rojas, Daniela
• Aristizabal, Juliet
• Arce, Bárbara
• Parra, Carolina
• Acevedo, Cristian
• Orellana, Nicole
• Reyes-Valenzuela, Mauricio
• Gotor, Francisco José
• Arévalo, Cristina
• Torres, Yadir

Titel

Graphene-coated Ti-Nb-Ta-Mn foams: A promising approach towards a suitable biomaterial for bone replacement

Ist Teil von

• Surface & coatings technology, 2020-11, Vol.401, p.126250, Article 126250

Ort / Verlag

Lausanne: Elsevier B.V

Erscheinungsjahr

2020

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The design of bone implants with proper biological and mechanical properties remains a challenge in medical implantology. The use of bioactive coatings has been shown to improve the biocompatibility of the implant surface. In this study, a new approach including porous scaffolds, β-Ti alloys and nanocoatings to design new bone implants is presented. Porous Ti-Nb-Ta-xMn alloys (x: 2, 4, and 6 wt%) substrates were obtained by powder metallurgy and the effect of the porosity and Mn content on mechanical properties was studied. CVD single-layer graphene was transferred onto the porous substrates that presented the best mechanical response (x: 4 wt%) for further evaluation of in vitro cell behavior (biocompatibility and cell adhesion). Cytotoxicity and biocompatibility tests confirmed that cell adhesion and proliferation were successfully achieved on graphene-coated porous substrates, confirming these systems are potential candidates for using in partial bone tissue replacement. •Ti-based alloy foam is proposed and studied for bone implant applications.•Porous TiNbTaMn samples were obtained by powder metallurgy and space holder technique.•4 wt% Mn content favors the presence of Ti β-phase and lower Young's modulus.•CVD-grown graphene coating was used to improve the biocompatibility of Ti alloy.•Graphene coating promotes cell growth and adhesion on Ti-35Nb-29Ta-4Mn substrate.