Details

Autor(en) / Beteiligte

• Ott, Colby E.
• Cunha-Silva, Hugo
• Kuberski, Sara L.
• Cox, Joseph A.
• Arcos-Martínez, M. Julia
• Arroyo-Mora, Luís E.

Titel

Electrochemical detection of fentanyl with screen-printed carbon electrodes using square-wave adsorptive stripping voltammetry for forensic applications

Ist Teil von

• Journal of electroanalytical chemistry (Lausanne, Switzerland), 2020-09, Vol.873, p.114425, Article 114425

Ort / Verlag

Amsterdam: Elsevier B.V

Erscheinungsjahr

2020

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Square-wave adsorptive stripping voltammetry (SWAdSV) is proposed as a fast, simple, and sensitive approach toward the detection, identification, and semi-quantitation of fentanyl in seized drug samples using screen-printed carbon electrodes. Electrochemical oxidation of fentanyl resulted in the formation of two anodic peaks, one at 0.75 V (peak I) and the second at 0.88 V (peak II) versus a Ag/AgCl pseudo reference electrode. Voltammetric measurements were conducted under optimized experimental conditions using fentanyl standards ranging from 0.076 μg/mL to 6.9 μg/mL, which resulted in a limit of detection of 0.037 μg/mL. Reproducibility was assessed as the average percent relative standard deviation of the slopes of calibration curves and was 2.6% for oxidation peak I and 7.4% for oxidation peak II in cell. Detection capabilities were assessed in a 5-mL cell and in a 100 microliter drop. Interference studies were conducted with cocaine, methamphetamine, quinine, caffeine, and acetaminophen. The mechanism for the electrochemical oxidation of fentanyl to norfentanyl is also described. Accuracy and suitability of the method for seized drug analysis was assessed using 11 simulated samples. Suitability of the method for future analysis of fentanyl in oral fluid was assessed. [Display omitted] •Screen-printed electrodes were used for a simple and rapid analysis of fentanyl.•Two anodic peaks were observed for the electro-oxidation of fentanyl.•Electro-oxidation of fentanyl occurs via N-dealkylation to norfentanyl.•Identification of fentanyl was achieved with common interferents and adulterants.•Accuracy of the method was examined using simulated samples.