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Expression of CUEDC2 in serous ovarian carcinoma and correlation with clinical characters
Ist Teil von
Jie fang jun yi xue za zhi, 2020-01, Vol.45 (12), p.1265
Ort / Verlag
Beijing: People's Military Medical Press
Erscheinungsjahr
2020
Link zum Volltext
Quelle
EZB Electronic Journals Library
Beschreibungen/Notizen
Objective To observe the expression of CUE domain protein 2 (CUEDC2) in serous ovarian carcinoma, analyze the correlation with the clinical characters. Methods The expressions of CUEDC2 in 75 ovarian serous carcinoma tissues and 20 fimbria tissues of fallopian tube were detected by immunohistochemical method, and the correlation was analyzed between positive expression of CUEDC2 and the expressions of estrogen receptor (ER) and progesterone receptor (PR). Results The expression of CUEDC2 in 75 patients with serous ovarian cancer, the grade of stage Ⅰ was 1.35±0.60, stage Ⅱ was 1.54±0.57, and stage Ⅲ was 1.78±0.71, stage Ⅳ was 2.13±0.27, and significant differences existed between each two groups (P=0.04). The score of CUEDC2 increased with FIGO stage, that is, the expression of CUEDC2 increased gradually. The score of CUEDC2 was significantly lower in the early stage of serous ovarian carcinoma than that in the late stage (P=0.04). According to the pathological grade, no significant difference existed among t