Details

Autor(en) / Beteiligte

• Schimenti, John C

Titel

Conditional surrender in one generation: determining the reproductive roles of mouse embryo lethal genes by embryo complementation

Ist Teil von

• Biology of reproduction, 2021-01, Vol.104 (1), p.8-10

Ort / Verlag

United States: Society for the Study of Reproduction

Erscheinungsjahr

2021

Quelle

Elektronische Zeitschriftenbibliothek (Open access)

Beschreibungen/Notizen

• The laboratory mouse is the most widely used animal model for studying the genetics and biology of mammalian development and reproduction. Embryonic stem cell (ESC) gene targeting technology, and the sophisticated genomic manipulations it allowed, was unique to this organism for a long period of time; this was a major factor in the mouse's rise to pre-eminence as a model system over the past three decades or so. The recent advent of CRISPR/Cas9 technology has democratized the application of genome editing to essentially all organisms. Nevertheless, the scientific infrastructure behind the mouse still makes it the organism of choice for studying molecular mechanisms of mammalian development, and for modeling human development and disease.