Details

Autor(en) / Beteiligte

• Liu, Ming‐Ho
• Zhang, Zhe
• Yang, Yu‐Chi
• Chan, Yang‐Hsiang

Titel

Polymethine‐Based Semiconducting Polymer Dots with Narrow‐Band Emission and Absorption/Emission Maxima at NIR‐II for Bioimaging

Ist Teil von

• Angewandte Chemie International Edition, 2021-01, Vol.60 (2), p.983-989

Auflage

International ed. in English

Ort / Verlag

Germany: Wiley Subscription Services, Inc

Erscheinungsjahr

2021

Quelle

MEDLINE

Beschreibungen/Notizen

• Deep‐penetration fluorescence imaging in the second near‐infrared (NIR‐II) window heralds a new era of clinical surgery, in which high‐resolution vascular/lymphatic anatomy and detailed cancerous tissues can be visualized in real time. Described here is a series of polymethine‐based semiconducting polymers with intrinsic emission maxima in the NIR‐IIa (1300–1400 nm) window and absorption maxima ranging from 1082 to 1290 nm. These polymers were prepared as semiconducting polymer dots (Pdots) in aqueous solutions with fluorescence quantum yields of 0.05–0.18 %, and they demonstrate promising applications in noninvasive through‐skull brain imaging in live mice with remarkable spatial resolution as well as signal‐to‐background contrast. This study offers a platform for future design of NIR‐IIa or even NIR‐IIb emitting Pdots. A novel series of polymethine‐based semiconducting polymers were synthesized for the first time and prepared as Pdots in water with both absorption and emission in the NIR‐II window. These Pdots can be further applied for deep‐tissue non‐invasive fluorescence imaging.