Details

Autor(en) / Beteiligte

• Depner, Martin
• Taft, Diana Hazard
• Kirjavainen, Pirkka V.
• Kalanetra, Karen M.
• Karvonen, Anne M.
• Peschel, Stefanie
• Schmausser-Hechfellner, Elisabeth
• Roduit, Caroline
• Frei, Remo
• Lauener, Roger
• Divaret-Chauveau, Amandine
• Dalphin, Jean-Charles
• Riedler, Josef
• Roponen, Marjut
• Kabesch, Michael
• Renz, Harald
• Pekkanen, Juha
• Farquharson, Freda M.
• Louis, Petra
• Mills, David A.
• von Mutius, Erika
• Ege, Markus J.

Titel

Maturation of the gut microbiome during the first year of life contributes to the protective farm effect on childhood asthma

Ist Teil von

• Nature medicine, 2020-11, Vol.26 (11), p.1766-1775

Ort / Verlag

New York: Nature Publishing Group US

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• Growing up on a farm is associated with an asthma-protective effect, but the mechanisms underlying this effect are largely unknown. In the Protection against Allergy: Study in Rural Environments (PASTURE) birth cohort, we modeled maturation using 16S rRNA sequence data of the human gut microbiome in infants from 2 to 12 months of age. The estimated microbiome age (EMA) in 12-month-old infants was associated with previous farm exposure ( β  = 0.27 (0.12–0.43), P  = 0.001, n  = 618) and reduced risk of asthma at school age (odds ratio (OR) = 0.72 (0.56–0.93), P  = 0.011). EMA mediated the protective farm effect by 19%. In a nested case–control sample ( n  = 138), we found inverse associations of asthma with the measured level of fecal butyrate (OR = 0.28 (0.09–0.91), P  = 0.034), bacterial taxa that predict butyrate production (OR = 0.38 (0.17–0.84), P  = 0.017) and the relative abundance of the gene encoding butyryl–coenzyme A (CoA):acetate–CoA-transferase, a major enzyme in butyrate metabolism (OR = 0.43 (0.19–0.97), P  = 0.042). The gut microbiome may contribute to asthma protection through metabolites, supporting the concept of a gut–lung axis in humans. Growing up in the rich microbial environment of a farm strongly influences the maturation of the gut microbiome in the first year of life, which helps protect against the development of asthma in children.