Details

Autor(en) / Beteiligte

• Li, Haichao
• Cao, Jun
• Wei, Qiuping
• Ma, Li
• Zhou, Kechao
• Yu, Zhiming
• Zeng, Sichao
• Zhu, Ruitong
• Yang, Wanlin
• Lin, Cheng-Te
• Meng, Lingcong

Titel

Antifouling nanoporous diamond membrane for enhanced detection of dopamine in human serum

Ist Teil von

• Journal of materials science, 2021-01, Vol.56 (1), p.746-761

Ort / Verlag

New York: Springer US

Erscheinungsjahr

2021

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• In vivo tracking or in vitro real sample analysis by electrochemistry is one of the most straight and useful methods in biosensor field. However, surface biofouling of electrodes by non-specific protein adsorption is inevitable and usually leads to a decrease in sensitivity. Here, we developed a Nafion-coated porous boron-doped diamond (NAF/pBDD) electrode with hydrophobic nanostructures to minimize the biofouling effect and selectively detect dopamine (DA). Larger active area was obtained by this procedure compared to a bare diamond electrode. The as-prepared electrode shows excellent antifouling property and enrichment capacity toward selective detection of dopamine (DA). The low background current of the BDD electrode and the enhanced signals enables a lower detection limit, 42 nmol L −1 , and a wider linear range, 0.1–110 μmol L −1 , for determination of DA in human serum. Additionally, the facile modified electrode demonstrated renewable property and long-term stability due to the fact that the antifouling nanostructures belong to its own.