Details

Autor(en) / Beteiligte

• Zheng, Bo-Xin
• She, Meng-Ting
• Long, Wei
• Xu, Yong-Yu
• Zhang, Yi-Han
• Huang, Xuan-He
• Liu, Wenjie
• Hou, Jin-Qiang
• Wong, Wing-Leung
• Lu, Yu-Jing

Titel

A small-sized benzothiazole-indolium fluorescent probe: the study of interaction specificity targeting c-MYC promoter G-quadruplex structures and live cell imaging

Ist Teil von

• Chemical communications (Cambridge, England), 2020-12, Vol.56 (95), p.1516-1519

Ort / Verlag

Cambridge: Royal Society of Chemistry

Erscheinungsjahr

2020

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A small-sized c-MYC promoter G-quadruplex selective fluorescent BZT-Indolium binding ligand was demonstrated for the first time as a highly target-specific and photostable probe for in vitro staining and live cell imaging and it was found to be able to inhibit the amplification of the c-MYC G-rich sequence (G-quadruplex) and down-regulate oncogene c-MYC expression in human cancer cells (HeLa). A small-sized and target-specific fluorescent probe reveals the presence of c-MYC DNA G4-structures in cells and shows anticancer activity.