Details

Autor(en) / Beteiligte

• Tham, Tristan
• Machado, Rosalie
• Russo, Daniel P
• Herman, Saori Wendy
• Teegala, Sushma
• Costantino, Peter

Titel

Viral markers in nasopharyngeal carcinoma: A systematic review and meta-analysis on the detection of p16 INK4a , human papillomavirus (HPV), and Ebstein-Barr virus (EBV)

Ist Teil von

• American journal of otolaryngology, 2021-01, Vol.42 (1), p.102762

Ort / Verlag

United States: Elsevier Limited

Erscheinungsjahr

2021

Quelle

MEDLINE

Beschreibungen/Notizen

• This study aimed to conduct a meta-analysis to investigate the distribution of EBV and HPV stratified according to histological NPC type. We performed a meta-analysis to produce pooled prevalence estimates in a random-effects model. We also performed calculations for attributable fractions of viral combinations in NPC, stratified according to histological type. There was a higher prevalence of HPV DNA in WHO Type I (34.4%) versus WHO Type II/III (18.4%). The attributable fractions of WHO Type I NPC was predominantly double negative EBV(-) HPV(-) NPC (56.4%), and EBV(-) HPV(+) NPC (21.5%), in contrast to the predominant infection in WHO Type II/III which was EBV(+) HPV(-) NPC (87.5%). Co-infection of both EBV and HPV was uncommon, and double-negative infection was more common in WHO Type I NPC. A significant proportion of WHO Type I NPC was either double-negative EBV(-)HPV(-) or EBV(-)HPV(+).