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Functional connectivity in migraineurs with photo‐, phono‐, or osmophobia: A static and dynamic resting‐state functional magnetic resonance imaging study
Ist Teil von
Neurology and clinical neuroscience, 2020-11, Vol.8 (6), p.390-398
Ort / Verlag
Tokyo: Wiley Subscription Services, Inc
Erscheinungsjahr
2020
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
Background
Migraine attacks are associated with photo‐, phono‐, and osmophobia, which may be caused by different pathophysiological mechanisms because they are not present in all migraineurs.
Aim
Here, we investigated differences in static and dynamic resting‐state functional connectivities between patients with and without photo‐, phono‐, or osmophobia.
Methods
Sixty‐two women with migraine with/without photo‐, phono‐, or osmophobia underwent 3‐T functional magnetic resonance imaging during the interictal phase. We compared static and dynamic resting‐state functional connectivities using region of interest‐to‐region of interest analysis of 91 cortical, 15 subcortical, and 26 cerebellar areas.
Results
The static resting‐state functional connectivity analysis showed that patients with photophobia had 18 different significant connectivity pairs, those with phonophobia had 15, and those with osmophobia had significantly higher connectivity between the right cerebellar lobule and brainstem. The dynamic resting‐state functional connectivity analysis showed that patients with photophobia had 16 different significant connectivity pairs, those with phonophobia had eight without main regions, and those with osmophobia had 14. Static and dynamic functional connectivity alterations in patients with phonophobia and osmophobia had no significant overlapping connectivity pairs.
Conclusion
Our results showed that static and dynamic resting‐state functional connectivities in migraineurs with and without photo‐, phono‐, or osmophobia differed.