Details

Autor(en) / Beteiligte

• Zeng, Fanjun
• Xu, Bin
• Zhu, Hongyuan
• Wu, Shaowei
• Liao, Guoqing
• Xie, Daipeng
• Huang, Luyu
• Qiao, Guibin
• Yang, Xianzhu
• Zhou, Haiyu

Titel

A cascade dual-targeted nanocarrier for enhanced alectinib delivery to ALK-positive lung cancer

Ist Teil von

• Biomaterials science, 2020-11, Vol.8 (22), p.644-6413

Ort / Verlag

England: Royal Society of Chemistry

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• Alectinib is a highly efficacious inhibitor for the treatment of anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC) in the clinic; however, serious adverse events (AEs) occurred in 44.0% of patients. Herein, we explored magnetic/TAT dual-targeted nanocarriers as delivery systems for alectinib. Magnetic targeting efficiently enhanced the extravasation of alectinib-loaded nanoparticles from vessels into the tumor tissue, while the TAT targeting reactivated in the tumor tissue significantly improved the tumor cellular uptake of the nanocarrier. As a result, this dual-targeted polymeric nanocarrier exhibited superior therapeutic effects and induced tumor shrinkage in vivo . Meanwhile, this dual-targeted nanocarrier also minimized alectinib-induced hepatotoxicity, providing an efficient strategy to extend the application of alectinib for NSCLC patients. A polymeric nanocarrier with a cascade of magnetic and TAT targeting enhanced the therapeutic efficacy of alectinib towards ALK-positive lung cancer.