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Spatio‐Temporally Reporting Dose‐Dependent Chemotherapy via Uniting Dual‐Modal MRI/NIR Imaging
Ist Teil von
Angewandte Chemie International Edition, 2020-11, Vol.59 (47), p.21143-21150
Auflage
International ed. in English
Ort / Verlag
Germany: Wiley Subscription Services, Inc
Erscheinungsjahr
2020
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Unpredictable in vivo therapeutic feedback of hydroxyl radical (.OH) efficiency is the major bottleneck of chemodynamic therapy. Herein, we describe novel Fenton‐based nanotheranostics NQ‐Cy@Fe&GOD for spatio‐temporally reporting intratumor .OH‐mediated treatment, which innovatively unites dual‐channel near‐infrared (NIR) fluorescence and magnetic resonance imaging (MRI) signals. Specifically, MRI signal traces the dose distribution of Fenton‐based iron oxide nanoparticles (IONPs) with high‐spatial resolution, meanwhile timely fluorescence signal quantifies .OH‐mediated therapeutic response with high spatio‐temporal resolution. NQ‐Cy@Fe&GOD can successfully monitor the intracellular release of IONPs and .OH‐induced NQO1 enzyme in living cells and tumor‐bearing mice, which makes a breakthrough in conquering the inherent unpredictable obstacles on spatio‐temporally reporting chemodynamic therapy, so as to manipulate dose‐dependent therapeutic process.
A spatio‐temporal feedback on the intratumoral catalytic Fenton reaction is described. It bridges dual‐modal MRI/NIR imaging, thereby conquering inherent unpredictable barriers in chemodynamic therapy. This approach paves a way to accurately evaluate .OH dose‐dependent feedback.