Details

Autor(en) / Beteiligte

• Liu, Ziwei
• Wu, Long-Fei
• Bond, Andrew D
• Sutherland, John D

Titel

Photoredox chemistry in the synthesis of 2-aminoazoles implicated in prebiotic nucleic acid synthesis

Ist Teil von

• Chemical communications (Cambridge, England), 2020-11, Vol.56 (88), p.13563-13566

Ort / Verlag

England: Royal Society of Chemistry

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• Prebiotically plausible ferrocyanide-ferricyanide photoredox cycling oxidatively converts thiourea to cyanamide, whilst HCN is reductively homologated to intermediates which either react directly with the cyanamide giving 2-aminoazoles, or have the potential to do so upon loss of HCN from the system. Thiourea itself is produced by heating ammonium thiocyanate, a product of the reaction of HCN and hydrogen sulfide under UV irradiation. A direct link from cyanamide to cyanosulfidic chemistry via thiourea was demonstrated. 2-Aminoazoles were generated by photoredox cycling under prebiotically plausible conditions.