Details

Autor(en) / Beteiligte

• ONJI, Keiko
• KOIKE, Toshiyuki
• POLAN, Mohammad Ali Akbor
• HASAN, Md Riasat
• ALTERHISHIG, Bayarchimeg
• RAO, Yaxin
• QIU, Youjin
• MATSUDA, Yasuhiro
• BESSHO, Kazuhisa
• SAITO, Takashi

Titel

Accelerated Effect of MatriStem on Dentin Regeneration in Rats

Ist Teil von

• Journal of Oral Tissue Engineering, 2020, Vol.18(1), pp.23-28

Ort / Verlag

Okayama: Japanese Association of Regenerative Dentistry

Erscheinungsjahr

2020

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• The purpose of the present study was to investigate the effect of MatriStem derived from porcine bladder on reparative dentin formation and pulp inflammation in vivo compared with mineral trioxide aggregate and calcium hydroxide that have been used for vital pulp therapy. Exposed pulp tissue in the maxilla first molar of 8-week-old Wistar rats was covered with those materials. The rats were sacrificed 4 weeks after the operation. We performed histological examination of hematoxylin and eosin-stained sections of teeth that underwent direct pulp capping, followed by morphometric analysis of formed reparative dentin and evaluation of pulp inflammation. At 4 weeks, MatriStem formed highly compact, intensively reparative dentin with dentinal tubules. MatriStem induced less pulp inflammation than calcium hydroxide. This study suggests that MatriStem is a biocompatible, biodegradable, and bioactive material with growth factors such as bone morphogenetic proteins for dentin regeneration.