Details

Autor(en) / Beteiligte

• Li, Wen
• Chen, Shu-Yi
• Hu, Wei-Nan
• Zhu, Mei
• Liu, Jia-Min
• Fu, Yi-Hong
• Wang, Zhen-Chao
• OuYang, Gui-Ping

Titel

Design, synthesis, and biological evaluation of quinazoline derivatives containing piperazine moieties as antitumor agents

Ist Teil von

• Journal of chemical research, 2020-09, Vol.44 (9-10), p.536-542

Ort / Verlag

London, England: SAGE Publications

Erscheinungsjahr

2020

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A series of novel quinazoline derivatives containing piperazine analogs are synthesized via substitution reactions with 6,7-disubstituted 4-chloroquinazoline and benzyl piperazine (amido piperazine). Potent antiproliferative activities are observed against A549, HepG2, K562, and PC-3 with N-(3-chlorophenyl)-2-(4-(7-methoxy-6-(3-morpholino-propoxy)quinazoline-4-yl)piperazine-1-yl)acetamidename C9 showing excellent activity. This active derivative was screened for cell migration ability, proliferation effects, and apoptosis against A549 and PC-3 cells, with the result showing biological activity almost equal to that of the control gefitinib.