Details

Autor(en) / Beteiligte

• Idogawa, Shinnosuke
• Yamashita, Koji
• Kubota, Yoshihiro
• Sawahata, Hirohito
• Sanda, Rioki
• Yamagiwa, Shota
• Numano, Rika
• Koida, Kowa
• Kawano, Takeshi

Titel

Coaxial microneedle-electrode for multichannel and local-differential recordings of neuronal activity

Ist Teil von

• Sensors and actuators. B, Chemical, 2020-10, Vol.320, p.128442, Article 128442

Ort / Verlag

Lausanne: Elsevier B.V

Erscheinungsjahr

2020

Quelle

Elsevier ScienceDirect Journals

Beschreibungen/Notizen

• •We fabricated a <10-μm diameter coaxial microneedle-electrode.•Applications include multichannel and local-differential neuronal recordings.•LFP and unit-activity were recorded from the mouse’s cortex in vivo.•SNR and firing rate were increased by the local-differential recording. Electrophysiological recording requires low invasive electrode geometry in the tissue and high-quality signal acquisitions. Here we propose a <10-μm diameter coaxial cable–inspired needle electrode, which consists of a core electrode in the needle surrounded by another shell electrode. The neuronal recording capability of these electrodes was confirmed by multichannel recording of a mouse cortex in vivo. Given that the shell electrode played the role of a reference electrode, the coaxial electrode also enabled a differential recording at the local area within the tissue. Compared to the recording without the referenced shell electrode, the differential recording demonstrated a twofold higher signal-to-noise ratio, while the firing rate increased. These results suggest that the coaxial microneedle-electrode will provide high-quality neuronal signals in electrophysiological recordings including ex vivo and in vitro applications, similar to the in vivo recording.