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•Anionic metal complexes are paired with cationic surfactants.•Surfactants chaperon and assemble complexes around a solid lipid nanoparticle core.•Metal complexes are crosslinked to enclose a solid lipid nanoparticle (SLN) core.•The reticulated metal complex/SLN system is stable and disperses in water.
Carboxylate-rich lanthanide complexes were employed as anion counterions to the cationic surfactant cethyltrimethylammonium (CTA) and assembled to form a shell around emulsifying wax nanoparticles. The anionic complexes consisted of lanthanide ions coordinated by the ligand DOTA-tetrahomoserine (DhS). In combination with CTA the complexes formed a surfactant system (CTA)[LnDhS] (Ln = Eu, Gd) with the nonpolar tail of CTA embedded in an emulsifying wax (EW) nanoparticle core. The DhS units were then crosslinked with divinylsulfone to form a shell around the EW core. Fluorescence and NMR data on the Eu complex were consistent with the formation of a stable polymeric shell around the wax core template. These results illustrate a general method that exploits electrostatic interactions to assemble capsules around solid lipid nanoparticles. Preliminary relaxivity measurements were carried out on particles with Gd-containing shells.